educratsweb logo


Researchers at Indian Institute of Technology (IIT) Guwahati has worked on out-of-the-box ideas that can help prevent or reduce short-term memory losses associated with Alzheimer’s disease.

The research team was headed by Prof. Vibin Ramakrishnan, Professor, Department of Biosciences & Bioengineering, IIT Guwahati, and Prof. HarshalNemade, Professor, Department of Electronics and Electrical Engineering, IIT Guwahati. They studied the neurochemical principles of Alzheimer’s, and explored new ways to prevent accumulation of neurotoxic molecules in the brain that are associated with short-term memory loss.

The IIT Guwahati team reports interesting methods such as application of low-voltage electric field, and the use of ‘trojan peptides’ to arrest aggregation of neurotoxic molecules in the brain. The scientists are assisted by research scholars Dr. Gaurav Pandey and Mr. JahnuSaikia in their work. The results of their studies have been published in reputed journals such as ACS Chemical Neuroscience, RSC Advances of Royal Society of Chemistry, BBA and Neuropeptides.

The development of a cure for Alzheimer’s disease assumes importance India as it has the third highest number of Alzheimer’s patients in the world, after China and US, with more than four million people falling prey to the memory loss associated with it. While current treatments only alleviate some of the symptoms of the disease, there is no disruptive therapeutic approach yet that can treat the underlying causes of Alzheimer’s.

“Approximately hundred potential drugs for treatment of Alzheimer’s disease have failed between 1998 and 2011, which shows the gravity of the problem,” says Dr. Ramakrishnan, who participates in worldwide efforts at finding cures for the disease.

A defining hallmark of Alzheimer’s is the accumulation of amyloid beta peptides in the brain. Dr. Ramakrishnan and Dr. Nemade seek methods to reduce the accumulation of these peptides, in order to arrest the progression of Alzheimer’s.

In 2019, the IIT Guwahati scientists found that application of a low-voltage, safe electrical field can reduce the formation and accumulation of toxic neurodegenerative molecules that cause short-term memory loss in Alzheimer’s disease.  They found that external electric/magnetic field modulates the structure of these peptide molecules, thereby preventing aggregation.

“Upon exposure to electric field, we could retard the degeneration of nerve cells to an extent of 17–35%. Objectively, this would translate to about 10 years delay in the onset of the disease”, says Dr. Ramakrishnan.

Working further in this area, the scientists explored the possibility of using ‘Trojan peptides’ to arrest aggregation of these neurotoxic molecules. The idea of using ‘Trojan peptide’ comes from mythological “Trojan Horse” used as subterfuge by the Greeks in the battle of Troy. The researchers have designed Trojan peptides by adopting a similar approach of ‘deceit’ to impede the aggregation of the amyloid peptide, arrest the formation of toxic fibrillar assemblies, and reduce poisoning of nerve cells that leads to memory loss.

“Our research has provided a different path that may extend the onset of the Alzheimer’s disease. However, it would take testing in animal models and clinical trials before bringing in such new therapeutic approaches into human treatment” say project coordinators, Dr. Ramakrishnan and Dr. Nemade.

IIT Guwahati discovers new ways to prevent memory loss due to Alzheimer
Contents shared By educratsweb.com

Memory power of Swami Vivekananda - Experience 2 (स्वामी विवेकानंद) #Motivational - Published on Friday July 3 2020
if you have any information regarding Job, Study Material or any other information related to career. you can Post your article on our website. Click here to Register & Share your contents.
For Advertisment or any query email us at educratsweb@gmail.com

RELATED POST
1 Simba Movie trailer Download | Talented India 
2 RRB Group C: Link for refund active, websites to claim
3 Bihar issues alert over bird flu outbreak, begins inspection of poultry farms, disinfection measures
4 आरबीआई दे रहा नौकरी का सुनहरा मौका
5
6 शिवराज का मप्र की राजनीति से अध्याय खत्म
7 PhonePe Scratch Card Offers - Chance to Earn Rs. 1000 Per Money Transfer
8 CG Vyapam Recruitment 2019 : कई पदों पर भर्तियां
9 IPL auction: Learn base price of players
10 Get the help to Find Land or Bhu Naksha UP by Digital Portal
11 On directions of the Prime Minister, Home Ministry approves release of Rs 11,092 crores under State Disaster Risk Management Fund to All States
12 NCC cadets start serving people during COVID-19 pandemic under Exercise NCC Yogdan
13 IIIT Guwahati keeps up the spirit of EBSB by holdingPoster Making Competition“RAJASTHAN TOURISM AND TRAVELS”under Ek Bharat Shreshtha Bharat Campaign
14 100 distilleries and more than 500 manufacturers permitted to produce hand sanitizers
15 India’s response to COVID outbreak
16 Finance Minister announces Rs 1.70 Lakh Crore relief package under Pradhan Mantri Garib Kalyan Yojana for the poor to help them fight the battle against Corona Virus
17 International Nurses Day observed
18 COVID-19: Relaxation from lockdown in Green zones
19 Effective Implementation of RERA can Restore Trust Between Buyer and Seller: Hardeep S Puri
20 Lower rate of EPF subscription 10% with EPFO notified placing higher liquidity in the hands of employees and employers during COVID -19 pandemic
21 LIST OF 200 (100 PAIRS) MAIL/EXPRESS TRAINS TO BE RUN WEF 01/06/2020
22 MHA to States: Cooperate with Railways in running more ‘Shramik Special’ Trains without any hindrance to facilitate faster movement of stranded Migrant Workers to their native places
23 GOM reviews containment measures of COVID-19
24 Food and Immunity: Correlation to combat against COVID-19
25 “Hunar Haat” to restart from September 2020 with the theme of “Local to Global”
26 Health Secretary interacts with 11 COVID-19 high case load municipal areas
27 IIT Guwahati discovers new ways to prevent memory loss due to Alzheimer
28 Violations of MHA Guidelines being reported at various places across the country
29 Union Minister Dr. Jitendra Singh launches Booklet and its e-version on one year achievements of Ministry of DoNER under Modi Government 2.0
30 IIT Guwahati develops affordable diagnostic kits for COVID-19
31 EPFO settles 36.02 lakh claims during lockdown
32 Around 76 Online Job Fairs conducted by NCS during lockdown
33 Twitter handle @LabourDG inaugurated by Shri Santosh Gangwar
34 Indian Railways ready to provide additional Shramik Special trains for any requirement given in future also
35 Shri Dharmendra Pradhan dedicates 56 CNG stations spread over 11 States/UTs;
36 Prime Minister Addresses the 25th Foundation Day of the Rajiv Gandhi University of Health Sciences
37 New study may help develop therapeutics for tongue cancer
38 Agroecology and Natural Farming Could Accelerate Inclusive Economic Growth in India
39 Union Minister Dr. Jitendra Singh inaugurates CAT Bench at Jammu.
40 Cabinet approves establishment of Pharmacopoeia Commission for Indian Medicine & Homoeopathy (PCIM&H) as Subordinate Office under Ministry of AYUSH
41 दिनांक 21 जून 2020 (31 ज्येष्ठ, शक संवत 1942) को वलयाकार सूर्य ग्रहण घटित होगा
42 Research proposals invited for COVID-19 for bilateral collaboration in science between India & Australia
43 Dry and chemical-free rapid disinfection through exposure to UVC light
44 Over 3000 COVID-19 samples tested at CSIR-NEERI
45 ASHAs of Odisha: overcoming COVID related stigma and discrimination
46 Center Bolsters Efforts for COVID Management in Delhi
47 Muslims from India will not go to Saudi Arabia to perform Haj 2020
48 Eco-friendly Synthesis of Gold Nanoparticles from Antarctic Bacteria for Therapeutic Use
49 Come, Innovate in India, Shri Dharmendra Pradhan appeals to Indian students from across the globe
50 INST scientists formulate nanoparticle to reduce severity of rheumatoid arthritis
We would love to hear your thoughts, concerns or problems with anything so we can improve our website educratsweb.com ! visit https://forms.gle/jDz4fFqXuvSfQmUC9 and submit your valuable feedback.
Save this page as PDF | Recommend to your Friends

http://educratsweb(dot)com http://www.educratsweb.com/content.php?id=2317 http://educratsweb.com educratsweb.com educratsweb