educratsweb logo


The Science and Engineering Research Board (SERB) underDepartment of Science & Technology (DST) has recently supported a proposed study by Prof. Pravindra Kumar from IIT- Roorkee for identification of structure-based potential antivirals against SARS-CoV2. 

 

The study to be funded under Intensification of Research in High Priority areas (IRHPA) will search for small molecule inhibitors targeting some of the most important viral replication enzymes. These enzymes are viral proteases (papain-like protease & 3CLprotease), RNA dependent RNA polymerase (nsp12), and the Methyltransferase or MTase (nsp14).Viral proteases, which are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens, catalyze the cleavage of specific peptide bonds in cellular proteins.

 

In this study, a computer-based high throughput virtual screening approach will be used to identify antiviral molecules from different compound libraries that will be experimentally validated for antiviral potential. The collaborators Dr. ShaillyTomar from IIT Roorkee and Dr. Gaurav Sharma from Indian Veterinary Research Institute (IVRI), Bareilly, will help in experimental testing and evaluation of the antiviral efficacy of the identified antiviral molecules against SARS-CoV-2 virus.

 

As a preliminary work, the investigators have already performed the in silico work by high-throughput virtual screening approach to examine the binding affinity of FDA approved drugs targeting the viral protease Mpro.

 

 

 

 

 

 

 

Figure: Three-dimensional structure focusing on the Mpro active site. The substrate peptide (black color) is shown to bound at the active site.

 

"The hunt for new drugs, including repurposed drug candidates, is getting a boost by in silico approaches, which allude to identifying the potential antiviral molecules based on computer simulation of their molecular structures. This approach is expected to be much faster and accurate in selection of potential drugs and vaccines for experimental and clinical testing.", said Prof Ashutosh Sharma, Secretary, DST.

 

SARS- CoV-2 is the etiological agent responsible for the global COVID-19 pandemic with high morbidity and mortality. Across the globe, the R&D activities by various agencies were initiated towards the identification of clinically effective vaccine or specific antiviral drugs or drug repurposing strategies to combat the COVID-19 infections either in the form of prevention or treatment.

 

Using structure-based approach for drug repurposing, this study would pave the way to identify the molecules that bind to Mpro active site, and their potential can be used as antiviral molecules against COVID-19.

 

educratsweb.com

Posted by: educratsweb.com

I am owner of this website and bharatpages.in . I Love blogging and Enjoy to listening old song. ....
Enjoy this Author Blog/Website visit http://twitter.com/bharatpages

if you have any information regarding Job, Study Material or any other information related to career. you can Post your article on our website. Click here to Register & Share your contents.
For Advertisment or any query email us at educratsweb@gmail.com

RELATED POST
1. Outstanding translation agency
Pangeanic is a professional translation agency that offers translation, website localization services and transcription services, always with professional results. The following are the different types of translations offered by the agency. Standard translation service One of its most popular translation services. Pangeanic translators produce high-quality translations, which are th
2. Private Sector Participation in Space Sector
Government has created Indian National Space, Promotion &Authorization Centre (INSPACe), under Department of Space to encourage, promote and hand hold the private sector for their participation in Space Sector. Private players will also be able to use ISRO infrastructure through INSPACe.The decision of Government was conveyed to the Members of the scientific community elaborately, and scientific community welcomed the Government decision. The role of New Space India Limited (NSIL) in the po
3. Prime Minister Narendra Modi to inaugurate the summit Responsible AI for Social Empowerment 2020 on October 5
Ministry of Electronics and Information Technology (MeitY) and NITI Aayog are organizing a Global Virtual Summit on Artificial Intelligence (AI), RAISE 2020- ‘Responsible AI for Social Empowerment 2020,’ from October 5-9, 2020. The Summit will be inaugurated by Prime Minister Shri Narendra Modi in the august presence ofMinister of Electronics & IT, Communications and Law &Justice, Shri Ravi Shankar Prasad, eminent global AI expert Professor R
4. Get Ready to Learn RPA Blue Prism
We are living in the midst of a digital era. Technology can enable us to  automate  business processes using Artificial Intelligence (AI) and software rather than people, wherever possible. A technology for this purpose is Robotic Process Automation (RPA). RPA can have a transformative impact on organizations by lowering costs, increasing reliability, and executing quickly. It can also let IT
5. India has Air Bubble Agreements with 10 Countries
India has entered into Air Bubble agreements with 10 countries viz. USA, Canada, France, Germany, UK, Maldives, UAE, Qatar, Afghanistan and Bahrain, till 13.09.2020. The essential details of Air Bubbles agreements are as follows: 1.         These are temporary agreements between two countries aimed at restarting commercial passenger services when regular international flights are suspended as a result of the COVID-19 pandemic. 2. 
6. Rajya Sabha passes Indian Institutes of Information Technology Laws (Amendment) Bill, 2020 today
Rajya Sabha passed Indian Institutes of Information Technology Laws (Amendment) Bill, 2020 in New Delhi today. The Indian Institutes of Information Technology Act of 2014 and Indian Institutes of Information Technology (Public-Private Partnership) Act, 2017 are the unique initiatives of the Government of India to impart knowledge in the field of Information Technology to provide solutions to the challenges faced by the country.The Indian Institutes of Information Technology Laws (Amendment) Bill, 2020 wa
7. Workshop to mark 20 years of Himalayan Chandra Telescope to highlight the science it produced
In the cold, dry desert of Ladakh, 4500 meters above the mean sea level, for two decades, the 2-m diameter optical-infrared Himalayan Chandra Telescope (HCT) at the Indian Astronomical Observatory (IAO) has been scanning the night sky in search of stellar explosions, comets, asteroids, and exo-planets. The telescope remotely operated using a dedicated satellite communication link from the Centre for Research & Education in Science & Technology (CREST), Indian I
8. The top Python developers in the United States
Python is a Swiss Army Knife for programmers. It is a veteran programming language present in many applications and operating systems. We can find it running on servers, in iOS, Android, Linux, Windows or Mac applications. This is because it has a moderate learning curve and because its philosophy emphasizes offering a readable code syntax. It is a versatile multiplatform and multiparadigm programming language that stands out for its readable and clean code. On
9. Education Minister virtually attends Diamond Jubilee Celebration of Commission for Scientific and Technical Terminology
Union Minister of Education Shri Ramesh Pokhriyal ‘Nishank’ virtually attended Diamond Jubilee Celebration of Commission for Scientific and Technical Terminology (Department of Higher Education) as Chief Guest today. Union Minister of State for Education Shri Sanjay Dhotre also attended the event through video conferencing as Guest of Honor. The Commission has done important work in the creation and development of Scientific and Technical Terminology for Hindi and other Indi
10. NTPC allowed to use drones for research and inspection of Thermal Power Projects
Ministry of Civil Aviation (MoCA) and Directorate General of Civil Aviation (DGCA) have granted conditional exemption to National Thermal Power Corporation (NTPC) for the deployment of Remotely Piloted Aircraft System (RPAS) for carrying out research and inspection activities at Vindhyachal Super Thermal Power Station, Madhya Pradesh, Gadarwara Super Thermal Power Plant, Madhya Pradesh, and Sipat Super Thermal Power Project, Chhattisgarh using drones. Shri Amber Dubey, Joint Secretary, Ministry
11. Government is implementing several schemes to encourage students/youth of the country towards the field of science and technology: Dr. Harsh Vardhan
It has been a part of Government’s Science and Technology (S&T) policy toencourage the students/youth of the country towards the field of science and technology. The first three key elements of Science, Technology, and Innovation (STI) Policy of 2013 Are: Promoting the spread of scientific temper amongst all sections of society. Enhancing skill for applications of science among the young from all social strata. Making careers in scienc
12. 11 Digital Education Tools For Teachers And Students
The Most Popular Digital Education Tools For Teachers And Learners Hundreds of digital education tools have been created with the purpose of giving autonomy to the student, improving the administration of academic processes, encouraging collaboration, and facilitating communication
13. CSIR-CMERI comes up with High Flow Rate Water Purification Technology for Fluoride and Iron Removal
NEED OF THE TECHNOLOGY: The contamination of fluoride and iron in drinking water is increasing day by day. Iron is the most abundant trace element in human body, responsible for accomplishment of vital biological functions such as gastrointestinal processes and the regulation of body temperature. But when iron level in water is beyond 0.3 ppm (as per WHO guideline), it shows several adverse effects including liver disease, irregular heart rhythm and neuronal disorder etc.
14. Swimming Fraternity welcomes resumption of Olympic training with sport-specific SOP issued by Sports Ministry
The Indian swimming fraternity has welcomed the decision to reopen swimming pools across the country. On Friday, the Sports Ministry issued the Standard Operating Procedures (SOP) outlining use of swimming pools for competitive swimmers. In its order dated September 30, the Union Home Ministry allowed for the reopening of swimming pools except for those in containment zones. Virdhawal Khade one of 6 Indian swimmers who has achieved the Olympic qualification B mark and who participated in the 20
15. National Super Computing Mission (NSM) is boosting high power computing in the country
India is fast expanding its supercomputer facilities and developing the capacity to manufacture its own supercomputers in the country. The National Super Computing Mission (NSM) is rapidly boosting high power computing in the country through its various phases to meet the increasing computational demands of academia, researchers, MSMEs, and startups in areas like oil exploration, flood prediction as also genomics, and drug discovery. With the infrastructure planned in NSM Phase-I alre
16. Successful Flight Test of SMART
Supersonic Missile Assisted Release of Torpedo (SMART) has been successfully flight tested today 5th Oct 2020 at 1145 hrs from Wheeler Island off the coast of Odisha. All the mission objectives including missile flight upto the range and altitude, separation of the nose cone, release of Torpedo and deployment of Velocity Reduction Mechanism (VRM) have been met perfectly. The tracking stations (Radars, Electro Optical Systems) along the coast and the telemetry stations including down range ships
17. Department of Science & Technology is having three binational Centres
Presently the Department of Science & Technology, Govt. of India is having three binationalCentres namely Indo-French Centre for Promotional of Advanced Research (IFCPAR)established with France in 1987, Indo-US Science & Technology Forum (IUSSTF) established in2000 with USA and Indo-German Science & Technology Centre (IGSTC) established in 2010under inter-governmental agreements. During last three years, the following new programmes have been launched by these binationalCentres:
18. Tata Motors Limited to supply 150 Nexon XZ+ electric compact SUVs & Hyundai Motor India Ltd. to supply 100 units of its Kona electric Premium SUVs
Energy Efficiency Services Limited (EESL), a Super Energy Service Company (ESCO) under the administrative control of Ministry of Power, Government of India, will procure 250 electric vehicles from Tata Motors and Hyundai Motor India. The companies were selected through an international competitive bidding process, which was aimed at increased participation. Tata Motors Limited and Hyundai Motor I
19. IPFT developes Bio-Pesticide Formulation for insect control in seed spice crops as safe alternative to chemical pesticides
 The institute of Pesticide Formulation Technology  (IPFT ) under the Department of Chemicals and Petrochemicals ,Ministry of Chemicals and Fertilizers in collaboration with ICAR- National Research Center on Seed Spices (NRCSS), Ajmer, Rajasthan has successfully developed new Aqueous Suspension formulation technology of bio-pesticide based on  entomo-pathogenic fungus Verticillium lecanii.  
20. Indian Astronomers discover one of the farthest Star galaxies in the universe.
As a landmark achievement in Space missions, Indian Astronomers have discovered one of the farthest Star galaxies in the universe.
21. CSIR-KPIT demonstrates Hydrogen Fuel Cell fitted car
Council of Scientific and Industrial Research (CSIR) and KPIT successfully ran trials of India’s first Hydrogen Fuel Cell (HFC) prototype car running on an indigenously developed fuel cell stack at CSIR-National Chemical Laboratory, Pune. The fuel cell is a low temperature PEM (Proton Exchange Membrane) type Fuel Cell that operates at 65-75 degree centigrade, which is suitable for vehicular applications.
22. Importance of Motorcycle Gears
Good motorcycle gear helps protect you from sun, rain, wind, noise, and debris, as well as pavement. It’s designed for more than just crash protection: it’s your second skin and protects you from sunburn, deafness from the wind, and anything that is flying through the air. Crash protection is the biggest benefit, however, and those of us who have come into contact with the pavement and have been saved by
23. Contour and Mphasis Partner to Accelerate the Digital Transformation of global Trade Finance
Contour and Mphasis Partner to Accelerate the Digital Transformation of global Trade Finance
24. From Touchless Soap & Water Dispenser, Mechanical Ventilator to Pioneering E-classroom Software or Low-cost Rapid Diagnostic Device and Innovating Air Providing Virus Destroying Mask, Covid 19 has forced Scientists to Seek for Fastest Innovations to Survive, Opine Researchers
Miss Digantika Bose studies in Class XII at Memari V M Institution Unit II, Burdwan. But in her tender age she is very much influenced by the principle of Thomas Alva Edison that ‘To invent, you need a good imagination and a pile of junk’. And as the proverb goes, Necessity is the mother of invention, Digantika has felt the utter helpless- ness of common people in the wake of Covid 19 pandemic to survive and has come up with Air Providing and Virus Destroying Mask which has received the accla
25. 321 Free Tools for Teachers - Free Educational Technology
Jacob Lund/Shutterstock.com Free Educational Technology for Teachers Do you support Free Technology for Teachers? If Yes, I highly encourage you to share this Free Educational Technology Reso
26 IAV KSCSTE Scientist and Technical Recruitment 2020 Vacancy #Scientist & Research 17 Days Remaining for Apply
Kerala State Council for Science, Technology and Environment (KSCSTE) is an autonomous body under the government of Kerala. Applications on prescribed format are invited for the Recruitment to the Government Job Vacancy posts of Scientist E2, Scientist-C, Technical Officer & Technical Assistant in the Institute of Advanced Virology (IAV), Thonnakal, Thiruvananthapuram (Kerala). ...
27 DRDO Scholarship Scheme for Girls in Aerospace Engg / Aeronautical Engg / Space Engg & Rocketry / Avionics / Aircraft Engg #Scholorship 16 Days Remaining for Apply
GOVT. OF INDIA, MINISTRY OF DEFENCE DEFENCE R&D ORGANIZATION (DRDO) DRDO Scholarship Scheme for Girls in Aerospace Engg / Aeronautical Engg / Space Engg & Rocketry / Avionics / Aircraft Engg Registrations will start from 19th July 2020 15th Aug 2020 onwards ...
28 Educational talent search program, ALLEN academics young talent search program for students | TALLENTEX 2021 #Scholorship 11 Days Remaining for Apply
Educational talent search program, ALLEN academics young talent search program for students | TALLENTEX 2021For student Studying in class 5th, 6th, 7th, 8th, 9th & 10th Stage-1 : Online | Stage-2 : Offline / CBT ...
29 Faculty Vacancy Recruitment at Cochin University of Science & Technology (CUSAT) 2020 #Faculty & Teaching 17 Days Remaining for Apply
Faculty Vacancy Recruitment at Cochin University of Science & Technology (CUSAT) 2020    Online application on prescribed format is invited from suitable candidates for following Faculty Government Jobs Vacancies in various departments of Cochin University of Science & Technology (CUSAT) and its affiliated colleges for the year 2020. (Advertisement No. : D2/136/Notif/2018) SarkariNaukriBlog dot com ...
30 IBPS 9th IX CRP RRB Officer Office-Assistant Recruitment 2020 #Bank 10 Days Remaining for Apply
 IBPS 9th IX CRP RRB Officer Office-Assistant Recruitment 2020 It has been decided by IBPS to reopen the registration window and invite applications for 9th (IXth) online examination (Preliminary and Main) for Group-A Officers and Multipurpose Office-Assistants (Clerical cadre) Posts in the Participating Organisations in continuation to the detailed advertisement dated 01/07/2020. ...
We would love to hear your thoughts, concerns or problems with anything so we can improve our website educratsweb.com ! visit https://forms.gle/jDz4fFqXuvSfQmUC9 and submit your valuable feedback.
Save this page as PDF | Recommend to your Friends

http://educratsweb(dot)com http://www.educratsweb.com/content.php?id=2390 http://educratsweb.com educratsweb.com educratsweb