educratsweb logo


IIT, BHU to re-purpose approved drugs from DrugBank database for treating COVID-19 by targeting SARS-CoV-2 main protease

The Science and Engineering Research Board has approved support for research at IIT (BHU) Varanasi to identify lead compound(s) from available and approved drugs for fast-track anti-SARS-CoV-2 drug molecule.

 

Scientists and healthcare professionals over the world are trying for a cure for the pandemic, which afflicts the world today. At present, available treatments are focused only on symptomatic relief to help the patient overcome the infection. Repurposing of pre-existing drugs could help circumvent both the time and money required to find an effective cure.

 

The research group of Prof. Vikash Kumar Dubey is working on developing new drug candidates against SARS-CoV-2 by exploring DrugBank (DrugBank is a database of FDA approved drug compounds. This database will be used for searching drug against SARS-CoV-2) database compounds as an inhibitor of SARS-CoV-2 main protease, a key enzyme required for SARS-CoV-2 assembly and multiplication. They will be carrying out extensive computational and experimental studies to identify an inhibitor of SARS-CoV-2 main protease.

 

Taking advantage of available crystal structure of the SARS-CoV-2 main protease, a structure-based inhibitor design will be done by the researchers from the available FDA approved drugs compounds in the DrugBank database.

 

Subsequently, experimental validation of the designed inhibitor(s) on recombinant SARS-CoV-2 Mpro Protein will be carried out. Various inhibitor parameters will be calculated to establish the effectiveness of the inhibition of the SARS-CoV-2 Mpro enzyme function. As the enzyme SARS-CoV-2 Mpro, is key for processing and polyprotein for virus assembly, the inhibition of this key protein can have an anti-viral effect. As most of DrugBank database compounds are characterized in terms of pharmacokinetics and toxicity, the identified molecule could be brought to the market rapidly. 

 

Description: VKD_SERB Story Final

 

 

IIT, BHU to re-purpose approved drugs from DrugBank database for treating COVID-19 by targeting SARS-CoV-2 main protease
Contents shared By educratsweb.com

if you have any information regarding Job, Study Material or any other information related to career. you can Post your article on our website. Click here to Register & Share your contents.
For Advertisment or any query email us at educratsweb@gmail.com

RELATED POST
1. Record highest single day recoveries of 56,110 registered
2. Gadkari calls for enhanced international investment in Infrastructure and MSME sector
3. Need for providing a comprehensive and objective account of the historical events: Vice President
4. MoRTH allows Sale and Registration of Electric Vehicles without batteries
5. Union Minister of Agriculture & Farmers Welfare Shri Narendra Singh Tomar launches Krishi Megh
6. Webinar on the occasion of the World Biofuel day organized
7. EPFO ensures hassle free service delivery through UMANG during COVID-19 pandemic
8. Highest ever single day recoveries of 54,859 today
9. PM launches financing facility of Rs. 1 Lakh Crore under Agriculture Infrastructure Fund
10. Letter of Recommendation module launched to include vendors who don’t have Identity Card and Certificate of Vending under PM SVANidhi
11. PM delivers inaugural addresses at the Higher Education Conclave
12. Shri Mansukh Mandaviya launches the Online Exit Examination system for seafarers
13. Unlocking Online Dispute Resolution to Enhance the Ease of Doing Business
14. Curriculum redesigning for NSNIS Diploma and strengthening faculty at NCSC among key decisions taken by SAI Academic Council
15. India and Japan are looking to have trusted partners from authentic investors: Shri Piyush Goyal
16. English rendering of text of PM’s speech at Higher Education Conclave
17. Delhi Airport develops portal for all international arriving passengers across India
18. TRIFED Reiterates its commitment towards transformation of tribal lives on the occasion of its Thirty-Third Foundation Day
19. 21 ESIC Hospitals Converted into Dedicated COVID-19 Hospitals Across the Country with the Facility of 2400 Isolation Beds: Santosh Gangwar
20. Pradhan Mantri Garib Kalyan Anna Yojana Phase-I
21. Union Minister Shri Ram Vilas Paswan urges States and UTs to fully implement One Nation One Ration Card scheme without any delay
22. Union Minister of Textiles and Women & Child Development, Smt Smriti Zubin Irani extends greetings on the occasion of the 6th National Handloom Day
23. Proposals for the construction of nearly 10.28 Lakh houses approved under PMAY(Urban)
24. IBBI amends the Insolvency and Bankruptcy Board of India (Insolvency Resolution Process for Corporate Persons) Regulations, 2016
25. PM to launch financing facility under Agriculture Infrastructure Fund and release benefits under PM-KISAN tomorrow
26. Indian products deserve fair access to other countries on reciprocal basis
27. Jal Jeevan Mission: A reservoir of clean water & employment opportunities
28. Eco-friendly Synthesis of Gold Nanoparticles from Antarctic Bacteria for Therapeutic Use
29. Trifed Launches its Own Virtual Office Network to Spearhead Tribal Socio-Economic Development on its 33rd Foundation day
30. World Class State of the Art Honey Testing Lab inaugurated at Anand, Gujarat
31. Aatma Nirbhar Bharat Package – Progress So Far
32. JNCASR spinoff launched molecular probes used in COVID-19 test kits
33. 1234 labs along with use of Rapid Antigen Tests drive Tests Per Million (TPM) to more than 9231
34. MoRTH notifies regulations for tyres, safety glass, external projections, etc under CMVR
35. National Institutes of Design students will be able to easily apply for work permits in Germany now, as NIDs have been included in the Anabin database, Germany
36. Indian Council of Agricultural Research celebrates its 92nd Foundation Day
37. Jal Jeevan Mission: Arunachal plans 100% tap connections by 2023
38. UPSC Gears up to Conduct Personaltiy Tests (Interviews) for the Civil Services Examination 2019 in the Backdrop of COVID-19 Pandemic
39. Two crore Building and Other Construction Workers (BOCW) received cash assistance of Rs 4957 crore during lockdown
40. Active respirator mask & nano-sanitiser developed by SNBNCBS can help in combatting COVID 19
41. The 8th convocation of NIPER Hyderabad held
42. Highest ever recoveries registered in a single day; more than 36,000 patients discharged
43. Manual Testing Online Course
44. Total 13.92% increase in sowing area coverage of kharif crops in comparison to last year
45. To combat Covid -19 , RCF comes out with a new product : Hand Cleansing Iso Propyl Alcohol (IPA) Based Gel
46. Government decides to allow Invalid Pension to Armed Forces Personnel with less than 10 years of qualifying service
47. WHO advises 140 tests/day/million population
48. TIFAC releases report on Active Pharmaceutical Ingredients- Status, Issues, Technology Readiness and Challenges
49. Department of Biotechnology and its Research Institution Accelerate development of COVID-19 Vaccines, Therapeutics and Diagnostics
50. Union HRD Minister and Minister of State for HRD jointly launch the first on-line NISHTHA programme for 1200 Key Resources Persons of Andhra Pradesh
We would love to hear your thoughts, concerns or problems with anything so we can improve our website educratsweb.com ! visit https://forms.gle/jDz4fFqXuvSfQmUC9 and submit your valuable feedback.
Save this page as PDF | Recommend to your Friends

http://educratsweb(dot)com http://www.educratsweb.com/content.php?id=2503 http://educratsweb.com educratsweb.com educratsweb