educratsweb logo


INST synthesises inorganic-organic hybrid compound that can inhibit breast, lung & liver cancer cells

Scientists from the Institute of Nano Science & Technology (INST), Mohali, an autonomous institute of the Department of Science and Technology Government of India, have synthesized a novel inorganic-organic hybrid compound that can inhibit breast, lung, and liver cancer cells, opening up new possibilities for metallodrugs.

The solid compound based on phosphomolybdate cluster, an inorganic salt of phosphomolybdic acid, belongs to the Polyoxometalates (POMs) family, which had earlier been identified to have antitumor potential. The team of scientists led by Dr. Monika Singh and Dr. Deepika Sharma has chalked out the mechanism by which the compound kills the cancer cells. The research has been published in the journal Dalton Transactions.

POMs are an evolving class of inorganic metal oxides, which over the last decades, established promising biological activities by the virtue of their great diversity in structures and properties.

In order to probe into the mechanism of how the cancer cells are attacked by the compound, the team synthesised it by hydrothermal method. The aqueous mixture of sodium molybdate, phosphorus acid, and bipyridine was heated in an acetate buffer solution of pH 4 at 160 °C for 72 hours.In vitro cytotoxicity of the compound was determined on breast cancer (MCF-7), lung cancer (A549) and liver cancer (HepG2) cells by the conventional MTT assay (used for assessing cell metabolic activity). The cytotoxic effect observed for the compound on the various cancer cell lines was further compared with that of a routinely used chemotherapeutic agent, Methotrexate (TCI), by the MTT assay.

The mechanism of cell death occurring in breast cancer (MCF-7), lung cancer (A549) and liver cancer (HepG2) cells was evaluated using an Alexa Fluor 488 annexin V/dead cell apoptosis kit (Invitrogen). To determine the effect of the synthesized materials on the cell division, cell cycle analysis for the MCF-7, A549, and HepG2 cell lines was done by using flow cytometry. The in vitro results showed that this hybrid solid is less toxic towards normal cells, and its antitumor activity was also found to be comparable with that of a routinely used chemotherapeutic agent, Methotrexate (MTX). 

In the past few decades, POMs have evolved as a promising candidate for future metallodrugs for combating cancer. The compound synthesized by the INST team could open new avenues for antitumor applications.

DST success story_Monika 2

[Publication: Joshi, A.; Gupta, R.; Singh, B.; Sharma, D.; & Singh, M., Effective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by phosphomolybdate based hybrid solid. Dalton Trans., 2020 DOI: 10.1039/D0DT01042A.

 

For more details, Dr. Monika Singh (monika@inst.ac.in,0172-2210075 (ext. 322)) can be contacted.]

https://pib.gov.in/PressReleasePage.aspx?PRID=1635081

educratsweb.com

Posted by: educratsweb.com

I am owner of this website and bharatpages.in . I Love blogging and Enjoy to listening old song. ....
Enjoy this Author Blog/Website visit http://twitter.com/bharatpages

if you have any information regarding Job, Study Material or any other information related to career. you can Post your article on our website. Click here to Register & Share your contents.
For Advertisment or any query email us at educratsweb@gmail.com

RELATED POST
1. DBT – ICAR Transfer of Technology of novel Brucella vaccine viz. Brucella abortusS19 delta per vaccine
Department of Biotechnology (DBT), facilitated Transfer of Technology of novel Brucella vaccine viz. Brucella abortus S19 delta per vaccine, through Video Conferencing (VC), earlier this week and an MoU was signed.  This vaccine was developed by ICAR-Indian Veterinary Research Institute (ICAR-IVRI), Izatnagar, Uttar Pradesh through a Network project on Brucellosis supported by DBT in which a gene was knocked out from Brucella abortus S19 strain. This vacci
2. Historic reform in Medical Education: National Medical Commission (NMC) constituted
Historic reform in the field of medical education has been effectedby the Union Government with the constitution of the National Medical Commission (NMC), along with four Autonomous Boards. With this, the decades old institution of the Medical Council of India (MCI) stands abolished. Along with NMC, the four Autonomous Boards ofUG and PG Medical Education Boards, Medical Assessment and Rating Board, and Ethics and Medical Registration Board have also been constituted to help the NMC in day to day functio
3. Commencement of Yoga Break at Work Place by the Ministry of AYUSH from today
Activities for promoting the “Yoga Break” protocol of the Ministry of AYUSH, which were suspended after the onset of the Covid-19 protocol, have been resumed with effect from today.  This five minute protocol is intended to introduce people at the work place to Yoga, and also to help them to take a break from the work schedule and to refresh and re-focus.  Yoga is an ancient Indian discipline intended to bring balance and well being of individuals to the physical, mental,
4. AYUSH Ministry organized National webinar on Nutrition Science and Advancements
As part of the “AYUSH for Immunity” campaign of the Ministry of AYUSH, Govt. of India, a webinar on Nutrition Science and Advancements, titled POSHAN AAHAR was conducted recently. Experts, researchers, Clinical Nutritionists, Surgeons and Yoga& Naturopathy physicians were participated in the webinar. The webinar was organised by the Central Council for Research in Yoga & Naturopathy (CCRYN), an Autonomous Body under the Ministry of AYUSH. The first session was by Prof Kalida
5. Incentives for ASHAs
The Ministry of Health & Family Welfare, Govt. of India has provisioned  additional incentive of Rs. 1000 per month under the “India COVID 19 Emergency Response and Health Systems Preparedness Package” to ASHAs for undertaking COVID 19 related activities for the period of their engagement in this work. Further the benefit under “Pradhan Mantri Garib Kalyan Package : Insurance Scheme for Health Workers Fighting COVID 19”, has been launched  to provide an insurance cov
6. Nursing Colleges in India
State-wise number of nursing colleges functional in the country is at Annexure – I. Health being a State Subject, opening of new nursing colleges falls under the purview of the respective State Governments However, 129 proposals have been received in Indian Nursing Council from States/UTs under Section 13 and 14 of INC Act for opening of B.Sc. (Nursing) programme across the country in 2020-21.  State-wise details are at Annexure-II. The training being provided in the Nursin
7. TB cases in India
As per the Global TB Report 2019, the estimated number of cases and death rate in India has reduced from 2015 as under:   Year Incidence Mortality 2015 217/l
8. Nursing Colleges
State-wise number of nursing colleges functional in the country is given below:   State-wise distribution of Nursing Colleges as on 31st March, 2020   State Institutions Total
9. National Bio-Material Centre
National Biomaterial Centre has been established at National Organ and Tissue Transplant Organisation (NOTTO), Safdarjung Hospital, New Delhi, an organisation under Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India and is fully functional. The Government of India is implementing National Organ Transplant Programme (NOTP) to promote organ donation across the country. Under this programme, an apex level National Organ and Tissue Transplant Organisa
10. Vaccines Being Developed to Combat Coronavirus
Central Drugs Standard Control Organisation (CDSCO) has informed that it has granted test license permission for manufacture of COVID-19 Vaccine for preclinical test, examination and analysis to the following manufacturers in India: M/s Serum Institute of India Pvt., Ltd., Pune Ms. Cadila Healthcare Ltd., Ahmadabad M/s Bharat Biotech International Ltd., Hyderabad Biological E Ltd., Hyderabad M/s Reliance Life Sciences Pvt Ltd., Mumbai
11. Who Guidelines on COVID Tests
The World Health Organization (WHO) has recommended 0.14 samples per day per 1000 or 140 tests per day per million population. As on 19th September, 2020 India is conducting COVID -19 tests at a rate of 875 tests/million population per day. This is more than 6 times the WHO recommendations. For Tamil Nadu this stands at 1145 tests per million population per day. Indian Council of Medical Research in its advisory (issued on 4th September 2020) has allowed for ‘on-demand’ testing. Thi
12. 871 scheduled formulations of Essential medicines are covered under price control mechanism
Government has said that The National Pharmaceutical Pricing Authority (NPPA) has fixed the ceiling prices of 871 scheduled formulations of medicines under National List of Essential Medicines (NLEM), 2015.  The fixation of Ceiling price includes ceiling price of Cardiac Stents under Para 19 of the Drug Price Control Orders (DPCO), 2013 resulting in price reduction for Coronary Stents worked out up to 85% for Bare Metal Stents and 74% for Drug Eluting Stents. This information was
13. AYUSH Ministry supports a novel e-marathon as part of the Ayush for Immunity Campaign
The Ministry of AYUSH has joined hands with Rajagiri College of Social Sciences and Rajagiri Business School, Kochi to organise a novel e-marathon, as a part of the Ministry’s three-month campaign called “Ayush for Immunity”, focussing on desirable health-promotive and disease preventive steps. Combining technology, physical run, charity and wellness programs, this e-event is expected to add positivity and good health to the lives of the participants.
14. eSanjeevani OPD of Health Ministry completes 3 lakh tele-consultations within six months of launch
eSanjeevani OPD platform of Ministry of Health and Family Welfare has completed 3 lakh tele-consultations. This landmark milestone has been achieved within a short period of six months since its launch. eSanjeevani OPD services have enabled patient-to-doctor telemedicine in midst of the COVID-19 pandemic. This has helped in containing the spread of COVID by ensuring physical distancing and has simultaneously enabled provisions for non-COVID essential healthcare. The number of high tele-consulta
15. Indigenous Manufacturing of Medical Equipments
India is 86% import-dependent on Medical Devices/equipments. The various segments of devices/equipments imported are Electronics Equipment, Surgical Instruments, Conusumable& Disposables, IVD Reagent and Implants. Various schemes/initiatives have been formulated to promote domestic manufacturing of medical devices/equipments and attract large investment in the sector: National Biopharma Mission. DBT-AMTZ COMManD [Covid-19 Medtech Manufacturing Development] Conso
16. Reduction in Tobacco usage
Several steps have been taken by the Government to reduce the prevalence of tobacco use. Some of the major steps are as under; The Ministry of Health & Family Welfare has enacted a comprehensive legislation, namely the Cigarettes and Other Tobacco Products (Prohibition of Advertisement and Regulation of Trade and Commerce, Production, Supply and Distribution) Act, 2003 (COTPA 2003) to discourage the consumption of tobacco products in order to protect the masses from the health hazar
17. Fit India Dialogue focuses on the fitness interests of every age group and brings into play different dimensions of fitness: PM
Prime Minister Shri Narendra Modi launched the Age Appropriate Fitness Protocols on the occasion of the first anniversary of the Fit India Movement, via virtual conferencing today. Shri Modi interacted with various sports persons, fitness experts and others during the Fit India Dialogue event organised on the occasion. The virtual dialogue was conducted in a casual and informal manner where the participants shared with the Prime Minister their life experiences and their fitness mantra. 
18. President of India Shri Ram Nath Kovindwill confer the National Service Scheme (NSS) Awards for the year 2018-19 on 24th September, 2020
The President of India Shri Ram Nath Kovindwill confer the National Service Scheme (NSS) Awards for the year 2018-19 on 24th September, 2020 from Rashtrapati Bhawan, New Delhi through virtual mode. UnionMinister of Youth Affairs and SportsShri Kiren Rijiju will attend the ceremony from Vigyan Bhavan, New Delhi. The National Service Scheme (NSS) Award for the year 2018-19 will be given to 42 awardees in 3 different categories like University/ +2 Council, NSS Units and their Programme Officers and NSS Volu
19. Prime Minister to Review Status and Preparedness of COVID response and management in 7 High Focus States/UTs tomorrow
Prime Minister will chair a high level virtual meeting with the Chief Ministers and Health Ministers of seven COVID high burden States/UT to review the status and preparedness of COVID response and management, tomorrow, 23rd September 2020. These States/UT are Maharashtra, Andhra Pradesh, Karnataka, Uttar Pradesh, Tamil Nadu, Delhi and Punjab. More than 63% of the Active Cases of the country are concentrated in these seven States/ UT. They also account for 65.5% of the total confirmed
20. Cancer and Kidney related Diseases
The information regarding estimated incidence of cancer cases in the country is based on National Cancer Registry Programme (NCRP) of Indian Council of Medical Research. The latest report of NCRP is for the year 2020, which is based on data for the period 2012-16, as compared to earlier report of 2016, which was based on data for the period 2012-14. Also, the year 2020 report is based on an increased coverage in terms of more number of Population Based Cancer Registries (PBCRs) or expansion of some exist
21. Steps taken by the Government to Promote the Indian System of Medicines
To promote the education of Indian System of Medicines and Ayurveda globally, Ministry has signed 13 MoUs for setting up AYUSH Academic Chairs with foreign Universities/ institutes under which AYUSH experts are deputed in  reputed Universities/ institutes to undertake teaching/ training / research activities. Country to Country MoUs have been signed with 23 countries for cooperation in field of Traditional Medicine and Homoeopathy in which, amongst others, research, education, training, etc.  a
22. Ayurvedic Drugs and Protocol for COVID-19
A total of 247 proposals of Ayurveda interventions have been received under modified Extra Mural research (EMR) Scheme for SARS CoV-2 infection and COVID-19 disease. Out of 247 proposals, 21 research proposals recommended by competent authority on Ayurveda for SARS/COVID cases have been approved for funding. Ministry of AYUSH has formed an Inter-disciplinary AYUSH R&D Task Force. Task Force has formulated and designed clinical research protocols for prophylactic studies and add-on intervent
23. Primary Health Centres (PHCs)
Under the National Health Mission (NHM), Primary Health Centre (PHC) are established to cover a population of 30,000 in rural areas and 20,000 in hilly, tribal and desert areas. PHCs are established to cover defined population. As per the Rural Health Statistics-2019, as on 31.03.2019, a total of 24,855 rural PHCs and 5,190 urban PHCs have been functional in the country. State-wise details including for Rajasthan are given below: NUMBER OF PRIMARY HEALTH CENTRES (PHCs) FUNCTIO
24. Procedure for Research on Vaccine
The Central Drugs Standard Control Organisation (CDSCO) has informed that the requirements and guidelines to conduct clinical trial or grant of permission for marketing of new drugs including vaccines are prescribed under New Drugs and Clinical Trials Rules, 2019. Further, the Indian Council of Medical Research (ICMR), an autonomous organisation of the Department of Health Research, has informed that the stages of vaccine development include the following steps:   i. Id
25. COVID Cases and Sero Survey Status
India has one of the lowest cases per million population. It is 3445 for India as compared to 19295 for USA, 20146 for Brazil, 7283 for Russian Federation and 10929 for South Africa. However, cases per million population for India is high as compared to other countries in South East Asia   The low case fatality in India can be attributed to early case detection through community-based surveillance, containment measures including strict perimeter control, house-to-house case searc
26 बिहार तकनीकी सेवा आयोग | आयुष चिकित्सा पदाधिकारी की नियुक्ति हेतु विज्ञापान #Bihar 29 Days Remaining for Apply
बिहार तकनीकी सेवा आयोग | आयुष चिकित्सा पदाधिकारी की नियुक्ति हेतु विज्ञापान बिहा ...
27 ICMR Scientist-B vacancy Recruitment 2020 #Scientist & Research 7 Days Remaining for Apply
Indian Council of Medical Research (ICMR) under Department of Health Research, Ministry of Health & Family Welfare, Government of India will conduct a computer-based examination on 01/11/2020 for recruitment of various Scientist-B (Medical/Non-Medical) vacancy posts and hence invites online application on prescribed format from Indian nationals for filling up these Government Job Vacancy posts of Scientist-B in various disciplines. (Advertisement No. ICMR/SC-B/2020) ICMR Scientist-B Recruitmen ...
28 UPSC Government Jobs Vacancy Recruitment 10/2020 #UPSC 6 Days Remaining for Apply
Union Public Service Commission (UPSC), Dholpur House, New Delhi invites Online application on prescribed recruitment form by 01/10/2020 for following Sarkari Naukri Government Jobs vacancy posts especially Specialist (Faculty (Assistant Professor) and Assistant Director (Statistics - Census Operations etc. in various Central Government Departments/Organisations in the prescribed online format (Advt. No. 10/2020). UPSC Government Jobs Advt. No. 10/2020 Vacancies ...
29 TNUSRB recruitment 2020: Notification released for 10,908 to Police Constable, Jail Warder & other posts #Tamil Nadu 31 Days Remaining for Apply
Tamil Nadu Uniformed Service Recruitment Board (TNUSRB) on Thursday released a notification for the recruitment of Grade II Police Constable, Grade II Jail Warder, & Fireman vacancies on its official website. The interested candidates can apply online for TNUSRB common recruitment 2020 through the official website of TNUSRB — tnusrbonline.org — from September 26. The last date to submit the online applications for TNUSRB recruitment 2020 is October 26. The common recruitmen ...
30 Various Job in Institute of Company Secretaries of India (ICSI) #Jobs 5 Days Remaining for Apply
                                                              ICSI House , 22 , Institutional Area, Lodi Road, New Delhi –110003 ...
We would love to hear your thoughts, concerns or problems with anything so we can improve our website educratsweb.com ! visit https://forms.gle/jDz4fFqXuvSfQmUC9 and submit your valuable feedback.
Save this page as PDF | Recommend to your Friends

http://educratsweb(dot)com http://www.educratsweb.com/content.php?id=2791 http://educratsweb.com educratsweb.com educratsweb